Explore how we work and why we apply science and creativity for a better world to everything we do. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . . Catalog Number 102331. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . }o]X4]. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. Browse Avicel PH-101 and related products at MilliporeSigma. Powder becomes slippery when wet. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. 130. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. CAS 9004-34-6. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. SUBSTANCE IDENTIFICATION 1.1. SUBSTANCE IDENTIFICATION 1.1. MATERIAL SAFETY DATA SHEET Version: 1.0 1. endobj lH5JWy}DgKRR"Fs It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. Microcrystalline Cellulose Side Effects. 1 0 obj HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. Page 1 of 8. However, consumption of large quantities of the material may have a laxative effect. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. % Microcrystalline Cellulose NF. The cellulose molecule is formed through repeated condensation of cellobiose units. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Microcrystalline cellulose (C6H10O5)n is refined wood pulp. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. Are you sure you want to delete your template? The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . . There may be more fiber in your food than you realized. Heavy metals, % NMT 0.001 : CL-611NF Date Approved: 01/13/2010. Delivering efficient and robust formulations. 2 0 obj GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Terms and Conditions Compliance Solutions Industries About 3E News & Events . . Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. /Contents 4 0 R These grades have particle sizes ranging from <30 to approximately 200. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. endobj If you are already a ChemPoint customer then sign up for access to our online ordering website. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. <> MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. It is also inert and biocompatible. Origin(s): Plant/Botanical. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? However, it yields non-digestible fibre. It is, however, a good source of fibre. Report Category. POLYOX resins are nonionic polyethylene oxide solubility polymers. Avicel PH-101. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. CAS #: 9004-34-6 Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. 1.3. % Alginates from IFF are an excellent choice for consistent performance in a variety of applications. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. Cellulose microcrystalline for column chromatography. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Chemical Formula: (C6H10O5)n 1.4. %PDF-1.5 8 0 obj Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. : 9004-34-6 Date Approved: 01/31/2008 . Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! Performing this action will revert the following features to their default settings: Hooray! Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. Remove q9;v80q>jZ stream Avicel PH-200 microcrystalline cellulose NF, Ph. However, if handling bulk powders, observance of appropriate safeguards is recommended. . Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. : 160182. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. xv}O2' H~KEe9>G/,:9\i ( Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Aqueous suspensions of microcrystalline cellulose have . Earth Supplied Products LLC. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . >> Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. (Microcrystalline Cellulose Market Pr. [FMC Study Number I92-1464]. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. <> vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. 102331. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Gloves, eye protection and a dust mask should be used. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. Trademarks: Avicel PH-102. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm All Rights Reserved. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. 1.3. 4 0 obj It is also used in plaque assays for counting. No. stream Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. <> To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. common form is used in vitamin supplements or tablets. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> Quick Links. MATERIAL SAFETY DATA SHEET. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. <> SCMm_>x^O9l (n. Hi, let us know if you have any questions as you visit our website. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. Are you looking for information about products and services by region? X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Thus, Avicel contributes no or very few calories to the food system. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. stream )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . Product and Company Identification . The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. No. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. (1962). Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * PDF (28.38 mb) 2022 Corporate Fact Sheet. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. Superior Performance: Provides excellent water uptake and rapid swelling . Home. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ The typical mean particle size is 20200 m. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product.

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